Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Malonate → Diethyl isopentylmalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Malonate | HCID 7761 | — |
| 반응물 | 1-Bromo-3-methylbutane | HCID 7891 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl isopentylmalonate | HCID 79384 | — |
| 생성물 | Sodium ethoxide | HCID 2723922 | — |
반응 단계
Sodium ethoxide was prepared from sodium metal (9.1 g) and freshly distilled absolute ethanol (250 ml). Diethyl malonate (63.5 g) was added to sodium ethoxide in ethanol, and the mixture was stirred at 60°-70° C. for 50 min. Isoamyl bromide (60 g) was added, and the reaction mixture was heated under reflux overnight. After the usual work-up, the resulting crude product was distilled under reduced pressure to give diethyl isoamylmalonate. Yield : 71.7 g (78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05166174 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-4dbddbb96e704ff2a5630d54f6021cf3 |
| 출처 메모 | uspto-grants-1992_11 |