2,5-Dimethoxytetrahydrofuran → HCID 14986610, 화합물

HRID 373870노트

반응식

HRID 373870 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1.CO[CH:27]1[CH2:31][CH2:30][CH:29](OC)O1>C(O)(=O)C>[C:13]1([CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:9]2[CH2:10][CH2:11][N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]3[CH:27]=[CH:31][CH:30]=[CH:29]3)[CH2:7][CH2:8]2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 139569931-(4-Aminobutyl)-4-(diphenylmethyl)piperazine

생성물 1

HCID 14986610HCID 14986610, 화합물수율 64.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Under reflux, for 20 minutes is heated a solution of 1.28 g (3.96 mmoles) of 1-(4-aminobutyl)-4-diphenylmethylpiperazine and 0.77 g (5.8 mmoles) of 2.5-dimethoxytetrahydrofurane in 25 ml of acetic acid. It is cooled, it is poured over ice water, neutralized with NaCHO3 and extracted with chloroform. It is dried with Na2SO4, and evaporated under vacuum to dryness. 1.7 g of crude oil is obtained which is purified on a silica chromatographic column (eluant: ethyl acetate). 0.95 g of 1-[4-(4-Diphenylmethyl-1-piperazinyl)butyl]pyrrole is obtained in solid form, with a melting point 80°-84° C.

후처리

  1. temperatureUnder reflux, for 20 minutes
  2. temperatureIt is cooled
  3. extractionextracted with chloroform
  4. dry with materialIt is dried with Na2SO4
  5. customevaporated under vacuum to dryness
  6. custom1.7 g of crude oil is obtained which
  7. customis purified on a silica chromatographic column (eluant: ethyl acetate)

출처 및 근거

ORD 기록
ord-01eb4e09f7ec46e6914686cb10c101cc
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166205

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