HCID 10059379, 화합물 → (2S)-2-(methoxymethyl)morpholine hydrochloride
반응식
C([N:8]1[CH2:13][CH2:12][O:11][C@H:10]([CH2:14][O:15][CH3:16])[CH2:9]1)C1C=CC=CC=1.[ClH:17].O1CCOCC1>C(O)C.[C].[Pd]>[ClH:17].[CH3:16][O:15][CH2:14][C@H:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
(2S)-4-Benzyl-2-methoxymethylmorpholine (3 g) is dissolved in ethanol (50 ml) and thereto are added 4N hydrogen chloride/dioxane (3.4 ml) and 10% palladium-carbon (0.3 g), and the mixture is stirred under hydrogen pressure of 5 kg/cm2 at 40° C. for 6 hours. After removing palladium-carbon, the solvent is distilled off under reduced pressure. The residue is recrystallized from ethyl acetate-methanol to give the title compound (1.8 g).
후처리
- customAfter removing palladium-carbon
- distillationthe solvent is distilled off under reduced pressure
- customThe residue is recrystallized from ethyl acetate-methanol
출처 및 근거
- ORD 기록
- ord-ea16e6e580da41b89065e2ff08fac003
- 출처 데이터셋
- uspto-grants-1992_11
- 특허 번호
- US05166203
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