Ethyl Bromide → 4-Chloro-2,8-diethyl-6,7-dihydropyrimido[5,4-b][1,4]oxazin-7-one

HRID 374085노트

반응식

Br[CH2:2][CH3:3].[Cl:4][C:5]1[C:10]2[O:11][CH2:12][C:13](=[O:15])[NH:14][C:9]=2[N:8]=[C:7]([CH2:16][CH3:17])[N:6]=1>>[Cl:4][C:5]1[C:10]2[O:11][CH2:12][C:13](=[O:15])[N:14]([CH2:2][CH3:3])[C:9]=2[N:8]=[C:7]([CH2:16][CH3:17])[N:6]=1

참가 물질

반응물 2

HCID 6332Ethyl Bromide

HCID 198093774-chloro-6,7-dihydro 2-ethyl-8H-pyrimido[5,4-b][1,4]oxazin-7-one

생성물 1

HCID 199096264-Chloro-2,8-diethyl-6,7-dihydropyrimido[5,4-b][1,4]oxazin-7-one

실험 절차

Using the procedure of Example 80, except that 1-bromoethane was used instead of methyl iodide, 4-chloro-6,7-dihydro-2-ethyl-8H-pyrimido [5,4-b][1,4]oxazin-7-one was alkylated providing 4-chloro-2,8-diethyl-6,7dihydropyrimido [5,4-b][1,4]oxazin-7-one.

출처 및 근거

ORD 기록: ord-d645385d52324a6b9a5b692e9908a934
출처 데이터셋: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05166343

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