Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetate → 6-acetylamino-1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetate | HCID 175 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | m-Xylyl chloride | HCID 12102 | — |
| 반응물 | 6-acetylamino-1-methylhexahydro-1H-1,4-diazepine | HCID 15206155 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 6-acetylamino-1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepine | HCID 14998991 | — |
반응 단계
A mixture of acetate of 6-acetylamino-1-methylhexahydro-1H-1,4-diazepine (3.0 g), 3-methylbenzyl chloride (3.5 g), potassium carbonate (17 g), sodium iodide (0.1 g) and methyl ethyl ketone (200 ml) is refluxed with stirring for 16 hours. The reaction mixture is filtered, and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel with elution of chloroform-methanol (20:1). Fractions containing the title compound are pooled and evaporated under reduced pressure to give the title compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05166341 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-ad9e5766f2a34d56ae5126485c82708d |
| 출처 메모 | uspto-grants-1992_11 |