Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 374112생성일: 2026년 10월 25일
Tris(hydroxymethyl)nitromethane → 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine
https://huagongshe.com/reaction/374112
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tris(hydroxymethyl)nitromethane | HCID 31337 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | N~1~-Benzyl-N~2~-methylethane-1,2-diamine | HCID 10920861 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine | HCID 14938638 | — |
반응 단계
To a mixture of tris(hydroxymethyl)nitromethane (118.9 g), sodium bicarbonate (40 g) and water (1000 ml), N-benzyl-N'-methylethylenediamine (123 g) is added, and the reaction mixture is heated at about 50° C. for 2 hours. After cooling, the solution is extracted with dichloromethane, and the organic layer is washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The solvent is evaporated under reduced pressure to give 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05166341 |
|---|
| 출처 데이터셋 | uspto-grants-1992_11 |
|---|
| ORD ID | ord-a9b2f3e1505e4ee9b870b600161f91c4 |
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| 출처 메모 | uspto-grants-1992_11 |
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