Dimethylhydantoin → Nilutamide
반응식
C1(OC2C=CC=CC=2)C=CC=CC=1.[N+:14]([C:17]1[CH:22]=[CH:21][C:20](Cl)=[CH:19][C:18]=1[C:24]([F:27])([F:26])[F:25])([O-:16])=[O:15].[CH3:28][C:29]1([CH3:36])[NH:33][C:32](=[O:34])[NH:31][C:30]1=[O:35]>>[F:25][C:24]([F:27])([F:26])[C:18]1[CH:19]=[C:20]([N:31]2[C:30](=[O:35])[C:29]([CH3:36])([CH3:28])[NH:33][C:32]2=[O:34])[CH:21]=[CH:22][C:17]=1[N+:14]([O-:16])=[O:15]참가 물질
4
반응 조건
- 온도
- 200 °C
실험 절차
The following were introduced into 383.52 ml of phenyl oxide: 225.60 grams of 2-nitro-5-chloro-trifluoromethylbenzene, described in the German Patent No. DRP 637,318, 128.10 grams of 5,5-dimethylhydantoin described in Beil., Vol. 24, 289 and 198.53 grams of cuprous oxide. The mixture was heated to 200° C. for 24 hours, then cooled to 20° C. and filtered. The residue was rinsed with phenyl oxide, then extracted with ethyl acetate. The ethyl acetate phase was concentrated to dryness under reduced pressure at 60° C. and the residue was taken up in ammoniacal dichloroethane. The crystals obtained were dried at 60° C. to obtain 66.55 grams of crude product which, after purification from aqueous ethanol yielded 62.55 grams of purified desired product.