참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylhydantoin | HCID 6491 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Nilutamide | HCID 4493 | — |
반응 단계
30 ml of dimethylsulfoxide and 24.8 grams of 2-nitro-5-chloro trifluoromethylbenzene were introduced at 20° C. with stirring into 100 ml of dimethylsulfoxide, 12.80 grams of 5,5-dimethyl-hydantoin and 6.28 grams of potassium hydroxide in the form of flakes. The mixture was heated to 110° C. for a period of time variable between 3 and 18 hours. The product was characterized and determined by thin layer chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05166358 |
|---|
| 출처 데이터셋 | uspto-grants-1992_11 |
|---|
| ORD ID | ord-2ae4db263d7146fbaf6b90c5a74f8452 |
|---|
| 출처 메모 | uspto-grants-1992_11 |
|---|
