참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylhydantoin | HCID 6491 | — |
| 반응물 | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| 촉매 | Copper | HCID 23978 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Nilutamide | HCID 4493 | — |
반응 단계
71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05166358 |
|---|
| 출처 데이터셋 | uspto-grants-1992_11 |
|---|
| ORD ID | ord-f33c2a567db743aeaaf8f1ed8c025a89 |
|---|
| 출처 메모 | uspto-grants-1992_11 |
|---|
