Neopentylamine → N-cyano N'-(2,2-dimethylpropyl)-2-pyridinecarboximidamide

HRID 374132노트

반응식

HRID 374132 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][C:14]([CH3:18])([CH3:17])[CH2:15][NH2:16]>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH3:13])#[N:2]

참가 물질

4

반응물 2

HCID 79882NeopentylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

생성물 1

HCID 19734543N-cyano N'-(2,2-dimethylpropyl)-2-pyridinecarboximidamide수율 94%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 2,2-dimethylpropylamine (0.30 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from dichloromethane-diethyl ether to give the title compound (0.63 g, 2.9 mmol, yield: 94%) as colorless needles.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from dichloromethane-diethyl ether

출처 및 근거

ORD 기록
ord-b23c20c0a12a4d68b8fa69d5b39b103a
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166347

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