4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamide

HRID 374149노트

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HRID 374149 반응식
[C:1]([N:3]=[C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)OC(C)C)#[N:2].[CH3:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[N:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([CH3:15])=[CH:17][CH:18]=1)#[N:2]

참가 물질

4

반응물 2

HCID 660354-MethylbenzylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

생성물 1

HCID 19734558N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamide수율 92.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Isopropyl N-cyano-3-pyridinecarboximidate (0.50 g, 2.6 mmol) was dissolved in methanol (5 ml), and 4-methylbenzylamine (0.35 g, 2.9 mmol) was added. The mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the concentrated residue thus obtained was crystallized from diethyl ether to give the title compound (0.60 g, 2.4 mmol, yield: 91%) as colorless powder.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe concentrated residue thus obtained
  3. customwas crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-fa567d9da57c48daa5dc2e48e9e47c37
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166347

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