Acetic Acid → Methyl pyrazine-2-carboximidate

HRID 374185노트

반응식

HRID 374185 반응식
[C:1]([C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1)#[N:2].[C:9](O)(=[O:11])C>CO.C[O-].[Na+]>[N:4]1[CH:5]=[CH:6][N:7]=[CH:8][C:3]=1[C:1](=[NH:2])[O:11][CH3:9]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 73172Pyrazinecarbonitrile

생성물 1

HCID 470894Methyl pyrazine-2-carboximidate수율 910.8%

시약·촉매·용매 2

HCID 10942334Sodium Methoxide촉매HCID 887Methanol용매

실험 절차

Cyanopyrazine (5.26 g, 50 mmol) was dissolved in methanol (40 ml), and sodium methoxide (0.27 g, 5.0 mmol) was added. The reaction mixture was stirred at room temperature for 45 minutes. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Dichloromethane (50 ml) and diethyl ether (50 ml) were added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl pyrazinecarboximidate (6.87 g) as colorless powder.

후처리

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDichloromethane (50 ml) and diethyl ether (50 ml) were added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d37bdc5a23d64483aa74ed2f0ec6d4ae
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166347

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