Phenethylamine → N-cyano-N'-(2-phenylethyl)-3-furancarboximidamide

HRID 374192노트

반응식

HRID 374192 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)OC)#[N:2].[C:12]1([CH2:18][CH2:19][NH2:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)=[N:20][CH2:19][CH2:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)#[N:2]

참가 물질

4

반응물 2

HCID 1001PhenethylamineHCID 19734520Methyl N-cyano-3-furancarboximidate

생성물 1

HCID 19754249N-cyano-N'-(2-phenylethyl)-3-furancarboximidamide수율 79.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-3-furancarboximidate (0.30 g, 2.0 mmol) was dissolved in methanol (10 ml), and 2-phenylethylamine (0.27 g, 2.2 mmol) was added. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.38 g, 1.59 mmol, yield: 79%) as colorless crystals.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-147fd364e36749d098461403363edd79
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166347

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