Acetic Acid → Methyl 2-thiophenecarboximidate

HRID 374193노트

반응식

HRID 374193 반응식
[C:1]([C:3]1[S:4][CH:5]=[CH:6][CH:7]=1)#[N:2].C[O-].[Na+].[C:11](O)(=[O:13])C>CO>[S:4]1[CH:5]=[CH:6][CH:7]=[C:3]1[C:1](=[NH:2])[O:13][CH3:11]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 660872-ThiophenecarbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 398427Methyl 2-thiophenecarboximidate수율 817.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-cyanothiophene (5.46 g, 50 mmol) was dissolved in methanol (25 ml), and sodium methoxide (0.27 g, 5 mmol) was added. The mixture was stirred at room temperature for 18 hours. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (40 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-thiophenecarboximidate (6.35 g) as a yellow oil.

후처리

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (40 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8cf7d2e265df4e02b61ed7c7f849188d
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166347

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