1-Chloro-2-fluoroethane → 2-(2-Fluoroethylthio)-phenylsulfonamide

HRID 374349

반응식

HRID 374349 반응식
C(N(CC)CC)C.[SH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16].Cl[CH2:20][CH2:21][F:22]>CO>[F:22][CH2:21][CH2:20][S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16]

참가 물질

4

반응물 2

HCID 129831-Chloro-2-fluoroethaneHCID 198097532-Mercaptophenylsulfonamide triethylamine salt

생성물 1

HCID 198097542-(2-Fluoroethylthio)-phenylsulfonamide수율 74.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5.8 g of the 2-mercaptophenylsulfonamide triethylamine salt obtained in accordance with Example H6 and 1.7 g of 2-chloro-1-fluoroethane in 40 ml of methanol is stirred in a bomb tube for 23 hours at a temperature of +50° to +55° C. The reaction mixture is then evaporated and water is added to the residue which remains. The mixture is extracted with ethyl acetate, and the organic phase is washed and dried. Evaporation of the solution gives 3.5 g of 2-(2-fluoroethylthio)-phenylsulfonamide (74.5% of theory) having a melting point of +83° to +85° C.

후처리

  1. customThe reaction mixture is then evaporated
  2. additionwater is added to the residue which
  3. extractionThe mixture is extracted with ethyl acetate
  4. washthe organic phase is washed
  5. customdried
  6. customEvaporation of the solution

출처 및 근거

ORD 기록
ord-ed4db594ab6449c09e87eb753c4cf549
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166430

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