참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Fluoxetine | HCID 3386 | — |
반응 단계
A mixture of 4.0 g (0.0357 mol) potassium t-butoxide, 30 ml of N-methylpyrrolidone, 5.0 g (0.0303 mol) of 1-phenyl-3-N-methylaminopropan-1-ol and 7.4 g (0.0410 mol) of 1-chloro-4-trifluoromethylbenzene was heated to 140° C. and the reaction mixture was agitated at this temperature for 3 hours. The mixture was then cooled to 20°-25° C. and 40 ml of toluene and 60 ml of water were added. The layers were separated and water-phase was extracted with 40 ml of toluene. The combined toluene-phases were washed four times with 20 ml of water. Toluene was evaporated under reduced pressure yielding 7.19 g of the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05166437 |
|---|
| 출처 데이터셋 | uspto-grants-1992_11 |
|---|
| ORD ID | ord-b34bae52177e4aeaa7f77a82ff9cb36a |
|---|
| 출처 메모 | uspto-grants-1992_11 |
|---|
