Hexane → 4-(3-t-Butylureidomethyl)-1-aminomethylbenzene

HRID 374374

반응식

HRID 374374 반응식
[C:1]1([CH2:9][NH2:10])[CH:6]=[CH:5][C:4]([CH2:7][NH2:8])=[CH:3][CH:2]=1.CCCCCC.[C:17]([N:21]=[C:22]=[O:23])([CH3:20])([CH3:19])[CH3:18]>C(Cl)Cl>[C:17]([NH:21][C:22](=[O:23])[NH:8][CH2:7][C:4]1[CH:5]=[CH:6][C:1]([CH2:9][NH2:10])=[CH:2][CH:3]=1)([CH3:20])([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 8058HexaneHCID 62412tert-Butyl isocyanateHCID 683151,4-Benzenedimethanamine

생성물 1

HCID 200967404-(3-t-Butylureidomethyl)-1-aminomethylbenzene수율 42.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2.7 g p-xylylenediamine in 100 ml methylene dichloride, was added slowly with stirring 10 ml of a n-hexan solution containing 990 mg t-butyl isocyanate under ice cooling. Stirring was continued at room temperature for two hours, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography, giving 1 g of 4-(3-t-butylureidomethyl)-1-aminomethylbenzene.

후처리

  1. distillationthe solvent was distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-284a5578654e45f49e0ae5dd23284035
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166429

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