Methanesulfonic Acid → 1-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

HRID 374429노트

반응식

HRID 374429 반응식
C[S:2]([OH:5])(=[O:4])=[O:3].[OH-].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]>O1CCCC1>[S:2]([O-:5])([O-:15])(=[O:4])=[O:3].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]

참가 물질

4

반응물 2

HCID 6395Methanesulfonic AcidHCID 196988161-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide

생성물 1

HCID 676602951-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1.09 mlg [sic] (16.78 mol; 1.61 g) of methanesulfonic acid is added to a solution of 1-methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide (3.48 g; 15.35 mol) dissolved in 100 ml of anhydrous tetrahydrofuran. The mixture is stirred under argon at room temperature for one hour. The precipitate which forms is filtered and then rinsed with ether.

후처리

  1. filtrationThe precipitate which forms is filtered
  2. washrinsed with ether

출처 및 근거

ORD 기록
ord-c030ad34ab36425c8415fa7c69c341ec
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480884

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