1-Naphthylamine → (6,7-Dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine

HRID 374476

반응식

HRID 374476 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1>CCO>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 86401-NaphthylamineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

생성물 1

HCID 18770835(6,7-Dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a 25 mL flask with 10 ml of abs. EtOH is added 0.137 g of 4-chloro-6,7-dimethoxyquinazoline and 0.087 g of 1-aminonaphthalene. The solution is heated to reflux whereupon the insoluble materials dissolve. After 5 minutes at reflux a precipatate forms. The solution is allowed to stir an additional 10 min before cooling and isolation of the product as the hydrochloride salt by simple filtration. High-vacuum drying of the solid provided analytically pure (6,7-dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine (0.142 g, white powder, m.p. 271°-273° C.

후처리

  1. temperatureThe solution is heated
  2. temperatureto reflux whereupon the insoluble materials
  3. dissolutiondissolve
  4. temperatureAfter 5 minutes at reflux a precipatate forms
  5. temperaturebefore cooling
  6. filtrationisolation of the product as the hydrochloride salt by simple filtration
  7. customHigh-vacuum drying of the solid

출처 및 근거

ORD 기록
ord-9d65bc1284d442979fe13ebd9cd064ac
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05480883

연결된 노트

불러오는 중…