N-Acetyl-L-Cysteine → HCID 178418393, 화합물

HRID 3745

반응식

HRID 3745 반응식
[CH3:1][CH:2]([CH2:17][CH3:18])[CH:3]([N:7]1[C:11](=[O:12])[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[S:8]1)[C:4]([OH:6])=[O:5].C(N[C@H:23]([C:26]([OH:28])=[O:27])[CH2:24][SH:25])(=O)C>CO>[C:11]([NH:7][SH:25]([CH2:24][CH2:23][C:26]([OH:28])=[O:27])[S:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[C:11]([NH:7][CH:3]([CH:2]([CH3:1])[CH2:17][CH3:18])[C:4]([OH:6])=[O:5])=[O:12])(=[O:12])[CH3:10]

참가 물질

4

반응물 2

HCID 12035N-Acetyl-L-CysteineHCID 178926623-Methyl-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)pentanoic acid

생성물 1

HCID 178418393HCID 178418393, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.58 g (2.2 mmol) of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid in 20 mL of methanol was treated with 0.36 g (2.2 mmol) of N-acetyl-L-cysteine and the reaction was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was triturated with 100 mL of 60° C. water. The water was decanted and the solid was dissolved in 50 mL of ethyl acetate. The organic solution was dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a white, solid foam, mp 85°-90° C.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was triturated with 100 mL of 60° C. water
  3. customThe water was decanted
  4. dissolutionthe solid was dissolved in 50 mL of ethyl acetate
  5. dry with materialThe organic solution was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-8b264e10282d462783a148a83796833e
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05734081

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