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Hydrogen Peroxide → 2-Bromo-4-chloro-5-fluoro-phenol

HRID 374610
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HRID 374610 반응식
[Br:1][C:2]1[CH:18]=[C:17]([Cl:19])[C:16]([F:20])=[CH:15][C:3]=1C(C1C=CC=C([N+]([O-])=O)C=1)=O.OO.BrC1C=C(Cl)C(F)=CC=1C(O)=[O:27].[N+](C1C=C(O)C=CC=1)([O-])=O.[N+](C1C=C(C=CC=1)C(O)=O)([O-])=O>OS(O)(=O)=O.O=S(=O)=O.O>[Br:1][C:2]1[CH:18]=[C:17]([Cl:19])[C:16]([F:20])=[CH:15][C:3]=1[OH:27]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

8

반응물 5

HCID 784Hydrogen PeroxideHCID 84973-Nitrobenzoic acidHCID 111373-NitrophenolHCID 18997595HCID 18997595, 화합물HCID 18997597HCID 18997597, 화합물

생성물 1

HCID 189975962-Bromo-4-chloro-5-fluoro-phenol

시약·촉매·용매 2

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트
HCID 962
Water
용매
HCID 24681Fuming sulfuric acid용매

실험 절차

The reaction of 35.8 g (0.1 mol) of 2-bromo-4-chloro-5-fluoro-3'-nitrobenzophenone in 150 g of 5% oleum with 9.7 g (0.2 mol) of 70% hydrogen peroxide solution gives a mixture (29.0 g) of 2-bromo-4-chloro-5-fluorophenol, 2-bromo-4-chloro-5-fluorobenzoic acid, 3-nitrophenol and 3-nitrobenzoic acid (proportions in GC area-%: 14, 35, 36, 15) after dilution (300 g of water), refluxing for 4 h and extraction with methyl tert-butyl ether after removal of the solvent.

출처 및 근거

ORD 기록
ord-8c69ef1134da4ccda0367bea60bc6026
출처 데이터셋
uspto-grants-1996_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05481032

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