4-Toluenesulfonyl chloride → N-(2-(o-Fluorobenzoyl)-4-nitrophenyl)-p-toluenesulphonamide

HRID 374628

반응식

HRID 374628 반응식
[NH2:1][C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12])=[O:5].[S:20](Cl)([C:23]1[CH:29]=[CH:28][C:26]([CH3:27])=[CH:25][CH:24]=1)(=[O:22])=[O:21]>N1C=CC=CC=1>[F:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[C:4](=[O:5])[C:3]1[CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=[CH:16][C:2]=1[NH:1][S:20]([C:23]1[CH:29]=[CH:28][C:26]([CH3:27])=[CH:25][CH:24]=1)(=[O:22])=[O:21]

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 676572-Amino-2'-fluoro-5-nitrobenzophenone

생성물 1

HCID 3023542N-(2-(o-Fluorobenzoyl)-4-nitrophenyl)-p-toluenesulphonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture containing 10 g of 2-amino-5-nitro-2'-fluorobenzophenone and 7.5 g of tosyl chloride is refluxed in 50 ml of pyridine for 24 hours. The solvent is evaporated off to dryness, water and ethyl acetate are added, an insoluble material is filtered off and the organic phase is washed with a dilute solution of hydrochloric acid, water and an aqueous solution of sodium chloride and then dried over magnesium sulfate and evaporated. The residue is chromatographed on silica and the expected product is eluted with DCM.

후처리

  1. customThe solvent is evaporated off to dryness, water and ethyl acetate
  2. additionare added
  3. filtrationan insoluble material is filtered off
  4. washthe organic phase is washed with a dilute solution of hydrochloric acid, water
  5. dry with materialan aqueous solution of sodium chloride and then dried over magnesium sulfate
  6. customevaporated
  7. customThe residue is chromatographed on silica
  8. washthe expected product is eluted with DCM

출처 및 근거

ORD 기록
ord-3cd3151d66c7437c86a3b83b45c13a04
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05481005

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