HCID 20788751, 화합물 → HCID 20788749, 화합물
반응식
C([O:5][C:6](=[O:27])[C@H:7]([CH3:26])[NH:8][C:9](=[O:25])[CH:10]([O:14][C:15]1[N:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[N:16]=1)[CH:11]([CH3:13])[CH3:12])(C)(C)C>FC(F)(F)C(O)=O>[CH3:22][O:21][C:19]1[CH:18]=[C:17]([O:23][CH3:24])[N:16]=[C:15]([O:14][CH:10]([CH:11]([CH3:13])[CH3:12])[C:9]([NH:8][C@H:7]([C:6]([OH:27])=[O:5])[CH3:26])=[O:25])[N:20]=1참가 물질
3
실험 절차
2 g of N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine tert-butyl ester (Example 1.023) are added to 20 ml of trifluoroacetic acid. After one hour, the reaction mixture is concentrated by evaporation, taken up in ethyl acetate, washed once with dilute hydrochloric acid, dried over sodium sulfate and again concentrated by evaporation, yielding N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine as a crystalline product; m.p.: 157°-160° C. (from ethyl acetate).
후처리
- concentrationthe reaction mixture is concentrated by evaporation
- washwashed once with dilute hydrochloric acid
- dry with material