Pyridine → 2-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

HRID 374961노트

반응식

HRID 374961 반응식
[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8](O)=[O:9])([CH3:4])[CH3:3].N1C=CC=CC=1.C(Cl)(=O)C([Cl:25])=O>C(#N)C>[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8]([Cl:25])=[O:9])([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 65578Oxalyl chlorideHCID 189963762-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoic acid

생성물 1

HCID 189963812-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoic acid (68.6 mg, 0.3 mmol) was weighed into a 1 dram septum-capped vial containing a micro stir bar under nitrogen. Dry acetonitrile (300 microliter), dry pyridine (24 microliter, 0.3 mmol) and oxalyl chloride (26 microliter, 0.3 mmol) were added in order to the vial using microliter syringes. The yellow homogeneous solution was stirred for 30 minutes to afford a solution of 2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoyl chloride.

후처리

  1. customseptum-capped vial
  2. additioncontaining a micro stir bar under nitrogen

출처 및 근거

ORD 기록
ord-8b539eb3fffa421bbe814e73e4d9a995
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05482974

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