Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethyl 2-bromooctanoate | HCID 95580 | — |
| 반응물 | HCID 178526856 | HCID 178526856 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate | HCID 10062368 | — |
반응 단계
4-Nitroimidazole (0.29 moles, 32.9 g in 30 ml DMF was treated portionwise with sodium hydride (0.29 moles, 11.6 g. 60% in mineral oil) and stirred for 45 minutes. Ethyl 2-bromooctanoate (0.29 moles, 73.1 g) was added dropwise over 1 hour. The reaction was stirred overnight at room temperature, poured onto ice water, and extracted with ethyl acetate. The organic phase was washed with brine, dried and concentrated to yield 91 g of ethyl 2-(4-nitro-1H-imidazol-1-yl)octanoate. (MS)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05484780 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-dbd66e6369174d8aa63f577dbde71f8d |
| 출처 메모 | uspto-grants-1996_01 |