Methanol → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-benzhydryloxy-2-oxoethoxy)iminoacetic acid

HRID 375272노트

반응식

HRID 375272 반응식
[C:1]1([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:8][C:9]([CH2:11][O:12][NH2:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=O)[C:27]([OH:29])=[O:28])[N:25]=1.CO>CN(C)C=O>[NH2:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:13]/[O:12][CH2:11][C:9]([O:8][CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:10])/[C:27]([OH:29])=[O:28])[N:25]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 127833204-Thiazoleacetic acid, 2-amino-alpha-oxo-HCID 23358405Benzhydryl 2-aminooxyacetate

생성물 1

HCID 13729185(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-benzhydryloxy-2-oxoethoxy)iminoacetic acid수율 76.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

16.5 g of O-diphenylmethoxycarbonylmethylhydroxylamine and 9.9 g of (2-amino-4-thiazolyl)glyoxylic acid are stirred for 3 hours at room temperature in 30 ml of dimethylformamide. The reaction mixture is introduced into 500 ml of methanol, and the resultant deposit is filtered off. 18 g of the title compound are obtained as colourless crystals. M.p.: 125°.

후처리

  1. filtrationthe resultant deposit is filtered off

출처 및 근거

ORD 기록
ord-733546d3950349afa788b8fa4e6a4fe4
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484928

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