Ethyl 2-aminooxypropanoate → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-ethoxy-1-oxopropan-2-yl)oxyiminoacetic acid

HRID 375273노트

반응식

HRID 375273 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=O)[C:8]([OH:10])=[O:9])[N:6]=1.[CH2:12]([O:14][C:15]([CH:17]([O:19][NH2:20])[CH3:18])=[O:16])[CH3:13]>CN(C)C=O.CO>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:20]/[O:19][CH:17]([C:15]([O:14][CH2:12][CH3:13])=[O:16])[CH3:18])/[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

5

반응물 2

HCID 548209Ethyl 2-aminooxypropanoateHCID 127833204-Thiazoleacetic acid, 2-amino-alpha-oxo-

생성물 1

HCID 13729186(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-ethoxy-1-oxopropan-2-yl)oxyiminoacetic acid수율 86.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

17.2 g of (2-amino-4-thiazolyl)glyoxylic acid are added whilst cooling with ice to a solution of 14.6 g of O-(1-ethoxycarbonylethyl)hydroxylamine in 20 ml of dimethylformamide. The solution is stirred for 12 hours without cooling, and then diluted with 180 ml of methanol. In order to complete crystallisation, stirring continues for 5 hours at -5°, and then the product is filtered off by suction and dried. 24.7 g (86%) of the title compound are obtained. M.p.: 166°.

후처리

  1. temperaturewithout cooling
  2. customcrystallisation
  3. stirringstirring
  4. waitcontinues for 5 hours at -5°
  5. filtrationthe product is filtered off by suction
  6. customdried

출처 및 근거

ORD 기록
ord-3d2a7f428fa34bbe8c29628851aae31b
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484928

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