Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethenyl)-1,3-dipropyl-, (E)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid | HCID 4644031 | — |
| 반응물 | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| 생성물 | 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethenyl)-1,3-dipropyl-, (E)- | HCID 6448808 | 65.2% |
반응 단계
Substantially the same procedure as in Reference Example 1 was repeated using 1.35 g (5.96 mmol) of 5,6-diamino-1,3-dipropyluracil and 1.35 g (6.55 mmol) of 3-(1,4-benzodioxan-6-yl)acrylic acid. Then, the resultant crude crystals were recrystallized from ethanol/water to give 1.54 g (yield 65%) of Compound 16 as white needles.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05484920 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-047c9d08536a44489e4489b3286740c9 |
| 출처 메모 | uspto-grants-1996_01 |