3-(2,4-Dimethoxyphenyl)prop-2-enoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,4-dimethoxyphenyl)ethenyl)-, (E)-

HRID 375294

반응식

HRID 375294 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:18]=1[CH:19]=[CH:20][C:21](O)=O>>[CH3:15][O:16][C:17]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:18]=1/[CH:19]=[CH:20]/[C:21]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

참가 물질

3

반응물 2

HCID 856363-(2,4-Dimethoxyphenyl)prop-2-enoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64488531H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,4-dimethoxyphenyl)ethenyl)-, (E)-수율 20%

실험 절차

Substantially the same procedure as in Example 7 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3diethyluracil and 2.89 g (13.9 mmol) of 2,4-dimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylformamide/ethanol to give 0.92 g (yield 20%) of Compound 68 as yellow crystals.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dimethylformamide/ethanol

출처 및 근거

ORD 기록
ord-5849e0e2147e4075a013afb0933396a6
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484920

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