5,6-Diamino-1,3-dimethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxy-3-methylphenyl)ethenyl)-1,3-dimethyl-, (E)-

HRID 375305

반응식

HRID 375305 반응식
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=1[NH2:8].[CH3:13][O:14][C:15]1[C:25]([CH3:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][C:16]=1[CH:17]=[CH:18][C:19](O)=O>>[CH3:13][O:14][C:15]1[C:25]([CH3:26])=[C:24]([O:27][CH3:28])[CH:23]=[CH:22][C:16]=1/[CH:17]=[CH:18]/[C:19]1[NH:1][C:2]2[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=2[N:8]=1

참가 물질

3

반응물 2

HCID 795015,6-Diamino-1,3-dimethyluracilHCID 534015772,4-Dimethoxy-3-methylcinnamic acid

생성물 1

HCID 64488701H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxy-3-methylphenyl)ethenyl)-1,3-dimethyl-, (E)-수율 28%

실험 절차

Substantially the same procedure as in Example 7 was repeated using 1.0 g (5.88 mmol) of 5,6-diamino-1,3dimethyluracil and 1.44 g (6.45 mmol) of 2,4 -dimethoxy-3methylcinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane to give 581 mg (yield 28%) of Compound 94 as pale yellow needles.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dioxane

출처 및 근거

ORD 기록
ord-b2fbccc5a4ab40d9b639e2bec4fb1360
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484920

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