HCID 3126210, 화합물 → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(4-butoxyphenyl)ethenyl)-1,3-diethyl-, (E)-

HRID 375309노트

반응식

HRID 375309 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH2:15]([O:19][C:20]1[CH:30]=[CH:29][C:23]([CH:24]=[CH:25][C:26](O)=O)=[CH:22][CH:21]=1)[CH2:16][CH2:17][CH3:18]>>[CH2:15]([O:19][C:20]1[CH:21]=[CH:22][C:23](/[CH:24]=[CH:25]/[C:26]2[NH:1][C:2]3[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=3[N:8]=2)=[CH:29][CH:30]=1)[CH2:16][CH2:17][CH3:18]

참가 물질

3

반응물 2

HCID 3126210HCID 3126210, 화합물HCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64488801H-Purine-2,6-dione, 3,7-dihydro-8-(2-(4-butoxyphenyl)ethenyl)-1,3-diethyl-, (E)-수율 53%

실험 절차

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 3.67 g (16.7 mmol) of 4-butoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 3.04 g (yield 53%) of Compound 104 as pale yellow needles.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

출처 및 근거

ORD 기록
ord-9a496baa15254ffd98c3f87ef40ee4b6
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484920

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