5-Methoxyindoleacetic acid → HCID 57039225, 화합물

HRID 375440

반응식

HRID 375440 반응식
Cl.[C:2]1([C:8]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]2[C:40](=[CH:41][CH:42]=1)[NH:39][CH:38]=[C:37]2[CH2:43][C:44](O)=[O:45]>>[C:26]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14]([C:44](=[O:45])[CH2:43][C:37]4[C:36]5[C:40](=[CH:41][CH:42]=[C:34]([O:33][CH3:32])[CH:35]=5)[NH:39][CH:38]=4)[CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

참가 물질

3

반응물 2

HCID 189865-Methoxyindoleacetic acidHCID 70218598(3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride

생성물 1

HCID 57039225HCID 57039225, 화합물수율 61.3%

실험 절차

By working in accordance with Example 4, starting from 0.8 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride and 0.41 g of (5-methoxy-3-indolyl)acetic acid, 0.66 g of (3aS,4S,7aS)-7,7-diphenyl-2-[(5-methoxy-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol is obtained in the form of a beige foam.

출처 및 근거

ORD 기록
ord-ee07b0fb2bda4665a30b365d9076a5b2
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484804

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