Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4'-Mercaptoacetanilide → 3-[3-(4-Acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4'-Mercaptoacetanilide | HCID 70777 | — |
| 반응물 | 3-(3,5-Difluorophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine | HCID 19935817 | — |
| 생성물 | 3-[3-(4-Acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine | HCID 19935846 | 54% |
반응 단계
Using an analogous procedure to that described in Example 6, 4-mercaptoacetanilide was reacted with 3-(3,5-difluorophenyl)-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine to give 3-[3-(4-acetamidophenylthio)-5-fluorophenyl]-3-methoxy-1-(2,2,2-trifluoroethyl)pyrrolidine in 54% yield, m.p. 127°-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420298 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-24f1aee3b6fd4676991b1100df3f8a97 |
| 출처 메모 | uspto-grants-1995_05 |