Benzo-1,3-dioxole-5-acetic acid → 2-(1,3-Dioxaindan-5-yl)ethan-1-ol

HRID 375576노트

반응식

HRID 375576 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][C:11](O)=[O:12])=[CH:4][C:3]=2[O:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][CH2:11][OH:12])=[CH:4][C:3]=2[O:2]1

참가 물질

4

반응물 2

HCID 76115Benzo-1,3-dioxole-5-acetic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 27598462-(1,3-Dioxaindan-5-yl)ethan-1-ol수율 90.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3,4-Methylenedioxyphenylacetic acid (18.0 g) was added portionwise over 30 minutes to a stirred, ice-cooled suspension of lithium aluminium hydride (4.0 g) in ether (400 ml) and the mixture was stirred at room temperature for two hours, quenched by the cautious addition of saturated aqueous ammonium chloride solution and filtered. The filtrate was washed with 10% aqueous sodium carbonate solution, dried over magnesium sulphate and evaporated to give the title compound as a pale yellow oil (15.01 g, 90%), which was characterised by its 1H-NMR spectrum.

후처리

  1. temperaturecooled
  2. customquenched by the cautious addition of saturated aqueous ammonium chloride solution
  3. filtrationfiltered
  4. washThe filtrate was washed with 10% aqueous sodium carbonate solution
  5. dry with materialdried over magnesium sulphate
  6. customevaporated

출처 및 근거

ORD 기록
ord-745dc2ab3062421ab362e02db49ab10b
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486527

반응 노트

불러오는 중…