Potassium Carbonate → Ethyl 5-(hydroxymethyl)furan-2-carboxylate
반응식
C([O:4][CH2:5][C:6]1[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][CH:7]=1)(=O)C.C([O-])([O-])=O.[K+].[K+]>O>[OH:4][CH2:5][C:6]1[O:10][C:9]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:8][CH:7]=1참가 물질
4
실험 절차
A solution of 5-acetoxymethyl-2-ethoxycarbonylfuran (Maybridge Chemical Co., Ltd., Tintagel, Cornwall, UK., 0.54 g, 2.5 mmol) and K2CO3 (0.352 g, 2.6 mmol) in 5:1THF/H2O (30 mL), was stirred for 17 hours at ambient temperature. The reaction mixture was concentrated in vacuo and the residue partitioned between CH2Cl2 and saturated aqueous NaHCO3. The organic phase was dried over MgSO4, filtered, and concentrated in vacuo to give 5-hydroxymethyl-2-carboethoxyfuran (0.32 g) as a yellow liquid which was used without further purification.
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- customthe residue partitioned between CH2Cl2 and saturated aqueous NaHCO3
- dry with materialThe organic phase was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-36d1399fc9484d16bde170c70531ca59
- 출처 데이터셋
- uspto-grants-1996_01
- 특허 번호
- US05486525
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