Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Cyanide → 2-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | [3-(Bromomethyl)oxetan-3-yl]methanol | HCID 529264 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile | HCID 11007909 | — |
반응 단계
A solution of 42 g (0.23 mol) of [3-(bromomethyl)oxetan-3-yl] methanol (produced according to Example 1) in 420 ml of ethanol was refluxed with 13 g (0.265 mol) of sodium cyanide for 18 hours. After cooling to room temperature, the precipitated sodium bromide was filtered off and the filtrate concentrated by evaporation. The residue was distilled at 0.4 torr. The yield of product as a colorless oil was 16 g (54 percent). The boiling point of the product was 107° C./0.4 torr. Other data concerning the product was:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05486622 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-3fcf3ec291cc42e19566979fd5a4612d |
| 출처 메모 | uspto-grants-1996_01 |