Sodium Cyanide → 2-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile

HRID 375696

반응식

HRID 375696 반응식
Br[CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][O:5][CH2:4]1.[C-:9]#[N:10].[Na+]>C(O)C>[OH:8][CH2:7][C:3]1([CH2:2][C:9]#[N:10])[CH2:6][O:5][CH2:4]1

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 529264[3-(Bromomethyl)oxetan-3-yl]methanol

생성물 1

HCID 110079092-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 42 g (0.23 mol) of [3-(bromomethyl)oxetan-3-yl] methanol (produced according to Example 1) in 420 ml of ethanol was refluxed with 13 g (0.265 mol) of sodium cyanide for 18 hours. After cooling to room temperature, the precipitated sodium bromide was filtered off and the filtrate concentrated by evaporation. The residue was distilled at 0.4 torr. The yield of product as a colorless oil was 16 g (54 percent). The boiling point of the product was 107° C./0.4 torr. Other data concerning the product was:

후처리

  1. filtrationthe precipitated sodium bromide was filtered off
  2. concentrationthe filtrate concentrated by evaporation
  3. distillationThe residue was distilled at 0.4 torr
  4. customwas 107° C.

출처 및 근거

ORD 기록
ord-3fcf3ec291cc42e19566979fd5a4612d
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05486622

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