참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| 반응물 | 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile | HCID 219740 | — |
| 반응물 | HCID 178514171 | HCID 178514171 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Cyano-1-methyl-5-(p-chlorobenzoylthioureido)-pyrazole | HCID 86749226 | 65% |
반응 단계
6.4 ml (50 mmol) of p-chlorobenzoyl chloride were added to a solution of 4.2 g (55 mmol) of ammonium isothiocyanate in 100 ml of acetone at about 20° C. Stirring was carried out for 30 minutes, after which a solution of 6.1 g (50 mmol) of 5-amino-4-cyano-1-methylpyrazole in 100 ml of acetone was slowly added dropwise at 50° C. This mixture was heated at the boil for 4 hours, cooled to about 25° C. and then diluted with 1000 ml of water. The product was extracted with ethyl acetate. Yield: 65%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05486618 |
|---|
| 출처 데이터셋 | uspto-grants-1996_01 |
|---|
| ORD ID | ord-1070cd6c4d1d44779b1534cb24d15279 |
|---|
| 출처 메모 | uspto-grants-1996_01 |
|---|
