Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Ethanethiol, 2-(diethylamino)-, hydrochloride (1:1) | HCID 16031 | — |
| 반응물 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 반응물 | Benzyl 2-Benzylacrylate | HCID 10912012 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate | HCID 19937709 | — |
반응 단계
The oil prepared in Step 10 (1.5 g, 5.95 mmol) is dissolved under argon in methanol (22 mL). To this solution is added 2-diethylaminoethanethiol hydrochloride (1 g, 5.95 mmol), piperidine (0.78 mL, 7.85 mmol) and benzyltrimethylammonium hydroxide (0.25 mL, 0.6 mmol) , and the mixture is stirred at room temperature for 16 hours. The solvent is removed on a rotary evaporator and then the residue is purified by flash chromotography on silica gel to give the pure title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05488066 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-334a18af66234b7a8a23fa306b8c14f5 |
| 출처 메모 | uspto-grants-1996_01 |