Formaldehyde → 4-Benzoyloxy-2-methylenebutanal

반응식

[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH:13]=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:16][NH2+]C.C=O>>[C:1]([O:9][CH2:10][CH2:11][C:12](=[CH2:16])[CH:13]=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 712Formaldehyde

HCID 110087524-Oxobutyl benzoate

HCID 12954980Dimethylazanium;chloride

생성물 1

HCID 189915294-Benzoyloxy-2-methylenebutanal

실험 절차

10 g (52 mmol) of 4-benzoyloxybutanal, 4.78 g (58.6 mmol) of dimethylammonium chloride and 4.6 ml (60.8 mmol) of formaldehyde solution (37%) are refluxed for one hour with stirring (bath temperature ~110° C.). The mixture is allowed to cool and is extracted three times with ether; the organic phases are combined, washed with saturated sodium chloride solution, dried over MgSO4, filtered and concentrated by evaporation. 4-benzoyloxy-2-methylenebutanal is obtained in the form of a yellowish oil which can be reacted without further purification.