Benzyl 4-ethoxycarbonylmethoxybutyrate → 4-Ethoxycarbonylmethoxybutyric acid

HRID 376156노트

반응식

HRID 376156 반응식
[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC1C=CC=CC=1)=[O:12])=[O:5])[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:5])[CH3:2]

참가 물질

4

반응물 1

HCID 18991532Benzyl 4-ethoxycarbonylmethoxybutyrate

생성물 1

HCID 223185004-Ethoxycarbonylmethoxybutyric acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

45 g (0.16 mol) of benzyl 4-ethoxycarbonylmethoxybutyrate 58 g are dissolved in 450 ml of tetrahydrofuran and the solution is hydrogenated under normal pressure at room temperature by addition of 4.5 g of 5% Pd/C. Upon cessation of hydrogenation, the catalyst is removed by filtration and the filtrate is concentrated by evaporation giving 4-ethoxycarbonyhnethoxybutyric acid which is further reacted without purification.

후처리

  1. customUpon cessation of hydrogenation, the catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated by evaporation

출처 및 근거

ORD 기록
ord-23d5883eda0740c087ac3e2173b23940
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05488140

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