Formaldehyde → 4-Ethoxycarbonylmethoxy-2-methylene-butanal

HRID 376159노트

반응식

HRID 376159 반응식
[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH:11]=[O:12])=[O:5])[CH3:2].[Cl-].[CH3:14][NH2+]C.C=O>>[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][C:10](=[CH2:14])[CH:11]=[O:12])=[O:5])[CH3:2]

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 12954980Dimethylazanium;chlorideHCID 189915874-Ethoxycarbonylmethoxybutanal

생성물 1

HCID 189915804-Ethoxycarbonylmethoxy-2-methylene-butanal

실험 절차

11 g (63.1 mmol) of 4-ethoxycarbonylmethoxybutanal, 5.8 g (71.4 mmol) of dimethylammonium chloride and 5.5 ml (73.5 mmol) of a 37% solution of formaldehyde are stirred for 1 hour at a bath temperature of 110° C. The reaction mixture is allowed to cool and extracted three times with CH2Cl2. The combined organic phases are dried over Na2SO4 and concentrated by evaporation giving 4-ethoxycarbonylmethoxy-2-methylene-butanal as a yellowish liquid which is further reacted without purification.

후처리

  1. temperatureto cool
  2. extractionextracted three times with CH2Cl2
  3. dry with materialThe combined organic phases are dried over Na2SO4
  4. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-89c1888346644a5bba3c894730438b7d
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05488140

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