Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (4-Methoxyphenyl)glycolonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (4-Methoxyphenyl)glycolonitrile | HCID 36571 | — |
반응 단계
To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420349 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-d70c30dd3e6440eaa4466dd6b2a1c444 |
| 출처 메모 | uspto-grants-1995_05 |