Hydrochloric Acid → (4-Methoxyphenyl)glycolonitrile

HRID 37625

반응식

HRID 37625 반응식
[C-]#N.[Na+].[CH3:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH:12]=[O:13])=[CH:10][CH:11]=1.[CH2:14]([N:16](CC)CC)C.Cl>C(O)C>[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([OH:13])[C:14]#[N:16])=[CH:8][CH:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 8471TriethylamineHCID 8929Sodium CyanideHCID 312444-Methoxybenzaldehyde

생성물 1

HCID 36571(4-Methoxyphenyl)glycolonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.

후처리

  1. aliquotIn situ sampling of the reaction mixture
  2. customthe reaction
  3. customto quench
  4. customthe reaction
  5. filtrationtHE solution is filtered
  6. customused in the next step without further purification
  7. customYield

출처 및 근거

ORD 기록
ord-d70c30dd3e6440eaa4466dd6b2a1c444
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05420349

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