Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 6-formylpyridine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl 6-(hydroxymethyl)picolinate | HCID 11513809 | — |
| 촉매 | HCID 178418406 | HCID 178418406 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Methyl 6-formylpyridine-2-carboxylate | HCID 12575850 | 79% |
반응 단계
A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06020345 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-7eeb93095125479cbb6978ebce1004e3 |
| 출처 메모 | uspto-grants-2000_02 |