Mezacopride → N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide-N-oxide, hydrochloride

HRID 3763

반응식

HRID 3763 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH:9][C:10](=[O:22])[C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])[CH2:2]2.C([O-])(=O)/C=C/C([O-])=[O:27]>>[ClH:17].[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH+:9]([O-:27])[C:10](=[O:22])[C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])[CH2:2]2

참가 물질

3

반응물 2

HCID 3047745MezacoprideHCID 5460307Fumarate

생성물 1

HCID 131715440N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide-N-oxide, hydrochloride

실험 절차

N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide, fumarate [1:1] is converted to the free base by partitioning with aqueous sodium hydroxide and methylene chloride. Using the procedure of Example 1, the free base is reacted with peracetic acid to obtain the N-oxide and finally with hydrogen chloride in isopropanol to give the hydrochloride.

후처리

  1. customby partitioning with aqueous sodium hydroxide and methylene chloride
  2. customthe free base is reacted with peracetic acid

출처 및 근거

ORD 기록
ord-bc32b8c0b4ec4edd970f899e38ffb207
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722834

연결된 노트

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