Ammonia → (S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid

HRID 376404노트

반응식

HRID 376404 반응식
N.[CH:2]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:15](=[O:28])[CH2:16][C@H:17]([NH:21]C(=O)C(F)(F)F)[C:18]([OH:20])=[O:19]>CO>[NH2:21][C@@H:17]([CH2:16][C:15]([C:3]1[CH:4]=[CH:5][C:6]2[O:7][C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[C:10]=2[CH:2]=1)=[O:28])[C:18]([OH:20])=[O:19]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 54131944(S)-4-dibenzofuran-2-yl-4-oxo-2-(2,2,2-trifluoroacetylamino)-butyric acid

생성물 1

HCID 53753679(S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid수율 100.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methanol (40 mL) was saturated with gaseous ammonia at room temperature. To this solution was added (S)-4-dibenzofuran-2-yl-4-oxo-2-(2,2,2-trifluoroacetylamino)-butyric acid (0.5 g, 0.0013 mol) obtained above in Example 1. The reaction mixture was stirred at room temperature for 24 hours and then concentrated to dryness in vacuo. The residue was recrystallized from boiling methanol to yield the title product as a white solid (0.37 g, quant); mp 182-187° C.

후처리

  1. customobtained above in Example 1
  2. concentrationconcentrated to dryness in vacuo
  3. customThe residue was recrystallized

출처 및 근거

ORD 기록
ord-0c3a4a0b4ac04365a65f28eeecadabf7
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020366

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