Nitric Acid → 4-Fluoro-2-nitrotoluene

HRID 376441

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.[N+:9]([O-])([OH:11])=[O:10].S(=O)(=O)(O)O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

반응물 3

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 9603p-Fluorotoluene

생성물 1

HCID 679654-Fluoro-2-nitrotoluene수율 81.1%

반응 조건

온도: 100 °C

실험 절차

4-Fluorotoluene (14 g) is added slowly with stirring to a solution of fuming nitric acid (18 g) and concentrated sulfuric acid (30 g) over 30 minutes and alternately warmed and cooled to keep the temperature between 40 and 50° C. This is followed by heating at 100° C. for 30 minutes more. The organic material is cooled and extracted with methylene chloride to give 16 g of 4-fluoro-2-nitrotoluene.

후처리

temperaturealternately warmed
temperaturecooled
customthe temperature between 40 and 50° C
temperatureThe organic material is cooled
extractionextracted with methylene chloride

출처 및 근거

ORD 기록: ord-2ee120e614af43e9892804db6475cb6a
출처 데이터셋: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06020379

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