Tetrahydrofuran → 5'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

HRID 376448노트

반응식

HRID 376448 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11](SC)=[CH:10][CH:9]=2)[CH:7]=1.O[O:19][S:20]([O-:22])=O.[K+].[CH2:24]1COCC1>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:20]([CH3:24])(=[O:22])=[O:19])=[CH:10][CH:9]=2)[CH:7]=1

참가 물질

6

반응물 3

HCID 8028TetrahydrofuranHCID 193619465'-Fluoro-2'-Formyl-4-MethylthiobiphenylHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 193619415'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

시약·촉매·용매 2

HCID 94433Tetrabutylammonium hydrogen sulfate촉매HCID 962Water용매2회

실험 절차

5'-Fluoro-2'-formyl-4-methylthiobiphenyl (10 mmol) (Example 1E) in THF (20 ml) is charged dropwise with oxone® (6 mmol) and tetrabutylammonium hydrogensulfate (1 mmol) in water (15 ml). The mixture is stirred at room temperature for 1 hour. The suspension is poured into water (300 ml), the precipitate is filtered off, is washed with water and is dried in vacuo to give the title product.

후처리

  1. filtrationthe precipitate is filtered off
  2. washis washed with water
  3. customis dried in vacuo

출처 및 근거

ORD 기록
ord-382c66dc8b9d4744a64ecbb415b1b451
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020379

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