Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride

HRID 376462노트

반응식

HRID 376462 반응식
[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5](O)=[O:6])[CH2:3]1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C=O)C>[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5]([Cl:14])=[O:6])[CH2:3]1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 27369371-methylpiperidine-3-carboxylic Acid

생성물 1

HCID 200260181-Methylpiperidine-3-carbonyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.

후처리

  1. customThe solvent was then evaporated

출처 및 근거

ORD 기록
ord-38471196f515436496682fd4efba0d12
출처 데이터셋
uspto-grants-2000_02
특허 번호
US06020368

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